Interstate 81 is the main north-south route to and through the Shenandoah Valley.
From the Northeast take Interstate 76 or Interstate 78 west to Interstate 81 south.
From the Northwest take Interstate 76 east to Interstate 70. At Hagerstown, MD take Interstate 81 south into the Shenandoah Valley.
To reach the Valley from the east, the main highways are Interstate 66, which brings you directly from the Washington, D.C. area and connects with I-81 near Strasburg, VA.
Interstate 64, which brings you directly from Richmond and connects with I-81 near Staunton. From the west, I-64 is again the most direct route, coming from West Virginia and linking to I-81 near Lexington, VA